Genomic determinants implicated in the glucocorticoid-mediated induction of KLF9 in pulmonary epithelial cells
Abstract
Ligand-activated glucocorticoid receptor (GR) elicits variable glucocorticoid-modulated transcriptomes in different cell types. However, some genes, including Krüppel-like factor 9 (KLF9), a putative transcriptional repressor, demonstrate conserved responses. We show that glucocorticoids induce KLF9 expression in the human airways in vivo and in differentiated human bronchial epithelial (HBE) cells grown at air-liquid interface (ALI). In A549...
Paper Details
Title
Genomic determinants implicated in the glucocorticoid-mediated induction of KLF9 in pulmonary epithelial cells
Published Date
Jan 1, 2021
Volume
296
Pages
100065 - 100065
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