Reply to “The endocannabinoid 2-arachidonoylglycerol inhibits endothelial function and repair through cannabinoid 1 (CB1) receptor”

The involvement of the cannabinoid receptor 1 (CB1) in mediating adverse vascular effects by endocannabinoids is a reasonable assumption, which matches the, oftentimes, dualistic perception of cannabinoid receptor biology. The short-lived nature of endocannabinoids makes them ideal messengers for local autocrine and paracrine communication, which is essential to atherogenesis and endothelial repair [ [1] Howlett A.C. Reggio P.H. Childers S.R....