Deep eutectic solvent-catalyzed Meyer-Schuster rearrangement of propargylic alcohols under mild and bench reaction conditions.

Published on Dec 8, 2020in Chemical Communications5.996
· DOI :10.1039/D0CC06584F
Nicolás Ríos-Lombardía17
Estimated H-index: 17
Luciana Cicco7
Estimated H-index: 7
(University of Bari)
+ 5 AuthorsJavier González-Sabín22
Estimated H-index: 22
The Meyer-Schuster rearrangement of propargylic alcohols into α,β-unsaturated carbonyl compounds has been revisited by setting up an atom-economic process catalyzed by a deep eutectic solvent FeCl3·6H2O/glycerol. Isomerizations take place smoothly, at room temperature, under air and with short reaction times. The unique solubilizing properties of the eutectic mixture enabled the use of a substrate concentration up to 1.0 M with the medium being recycled up to ten runs without any loss of catalytic activity.
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