Characterization of human adrenal cytochrome P450 11B2 products of progesterone and androstenedione oxidation

Volume: 208, Pages: 105787 - 105787
Published: Apr 1, 2021
Abstract
Cytochrome P450 (P450) 11B1 and 11B2 both catalyze the 11β-hydroxylation of 11-deoxycorticosterone and the subsequent 18-hydroxylation of the product. P450 11B2, but not P450 11B1, catalyzes a further C-18 oxidation to yield aldosterone. 11-Oxygenated androgens are of interest, and 11-hydroxy progesterone has been reported to be a precursor of these. Oxidation of progesterone by purified recombinant P450 11B2 yielded a mono-hydroxy derivative as...
Paper Details
Title
Characterization of human adrenal cytochrome P450 11B2 products of progesterone and androstenedione oxidation
Published Date
Apr 1, 2021
Volume
208
Pages
105787 - 105787
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