Response to CAR-T Therapy Can be Monitored Using Genome-Wide Sequencing of Cell-Free DNA in Patients with DLBCL

Diffuse large B-cell lymphoma (DLBCL), a subtype of non-Hodgkin lymphoma, has a five-year survival rate of up to 70%; however, approximately half of patients will ultimately relapse and/or become refractory to therapy. In this clinical setting, autologous chimeric antigen receptor T-cell (CAR-T) therapy has been approved by the United States Food and Drug Administration. While these therapies show significant promise, methods that enable...