Combined Nuclear Magnetic Resonance Spectroscopy and Mass Spectrometry Approaches for Metabolomics.

Published on Jan 12, 2021in Analytical Chemistry6.785
· DOI :10.1021/ACS.ANALCHEM.0C04371
Marine P. M. Letertre1
Estimated H-index: 1
(University of Nantes),
Gaud Dervilly7
Estimated H-index: 7
,
Patrick Giraudeau32
Estimated H-index: 32
(University of Nantes)
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Abstract
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2012
3 Authors (Norbert W. Lutz, ..., Ron A. Wevers)
14 Citations
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Metabolomics and lipidomics are new drivers of the omics era as molecular signatures and selected analytes allow phenotypic characterization and serve as biomarkers, respectively. The growing capabilities of untargeted and targeted workflows, which primarily rely on mass spectrometric platforms, enable extensive charting or identification of bioactive metabolites and lipids. Structural annotation of these compounds is key in order to link specific molecular entities to defined biochemical functi...
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#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 9
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Hepatic fibrosis (HF) is a typical consequence of various chronic liver diseases, and there is still no ideal drug for its treatment. Yinchen Wuling Powder (YCWLP), a famous traditional Chinese medicine prescription, is effective for the treatment of icteric hepatitis, hepatic fibrosis, non-alcoholic fatty liver disease and other liver diseases in clinical practices, however, the underlying mechanisms of YCWLP on HF is still unclear. In this study, 1H NMR and MS-based metabolomics analysis along...
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Precision medicine, space exploration, drug discovery to characterization of dark chemical space of habitats and organisms, metabolomics takes a centre stage in providing answers to diverse biological, biomedical, and environmental questions. With technological advances in mass-spectrometry and spectroscopy platforms that aid in generation of information rich datasets that are complex big-data, data analytics tend to co-evolve to match the pace of analytical instrumentation. Software tools, reso...
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#1Fei-Long Liu (WHU: Wuhan University)H-Index: 3
#2Tiantian Ye (WHU: Wuhan University)H-Index: 22
Last. Yu-Qi Feng (WHU: Wuhan University)H-Index: 81
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Polar phosphorylated metabolites are involved in a variety of biological processes and play vital roles in energetic metabolism, cofactor regeneration, and nucleic acid synthesis. However, it is often challenging to interrogate polar phosphorylated metabolites and compounds from biological samples. Liquid chromatography-mass spectrometry (LC/MS) now plays a central role in metabolomic studies. However, LC/MS-based approaches have been hampered by the issues of the low ionization efficiencies, lo...
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#2B. Le BizecH-Index: 27
Last. Gaud DervillyH-Index: 7
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Abstract Exposure to chemical hazards is a growing concern in today’s society, and it is of utmost interest to know the levels of exposure to chemicals and the risks associated with such exposure in order to implement effective health prevention strategies. Chemical risk analysis represents a complex and laborious task due to the large number of known substances, but also unknown compounds and emerging risks that must be addressed. In this challenging scenario, the study of metabolic perturbatio...
1 CitationsSource
#1Pierre MillardH-Index: 14
#2Serguei SokolH-Index: 11
Last. Jean-Charles PortaisH-Index: 38
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Stable-isotope labeling experiments are widely used to investigate the topology and functioning of metabolic networks. Label incorporation into metabolites can be quantified using a broad range of mass spectrometry (MS)and nuclear magnetic resonance (NMR)spectroscopy methods, but in general, no single approach can completely cover isotopic space, even for small metabolites. The number of quantifiable isotopic species could be increased, and the coverage of isotopic space improved, by integrating...
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