Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans
Abstract
Acute myeloid leukemia (AML) relapse after allogeneic hematopoietic cell transplantation (allo-HCT) has a dismal prognosis. We found that T cells of patients relapsing with AML after allo-HCT exhibited reduced glycolysis and interferon-γ production. Functional studies in multiple mouse models of leukemia showed that leukemia-derived lactic acid (LA) interfered with T cell glycolysis and proliferation. Mechanistically, LA reduced intracellular pH...
Paper Details
Title
Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans
Published Date
Oct 28, 2020
Volume
12
Issue
567
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