Silencing of miR-138-5p sensitizes bone anabolic action to mechanical stimuli

Volume: 10, Issue: 26, Pages: 12263 - 12278
Published: Jan 1, 2020
Abstract
Emerging evidence is revealing that microRNAs (miRNAs) play essential roles in mechanosensing for regulating osteogenesis. However, no mechanoresponsive miRNAs have been identified in human bone specimens. Methods: Bedridden and aged patients, hindlimb unloaded and aged mice, and Random Positioning Machine and primary aged osteoblasts were adopted to simulate mechanical unloading conditions at the human, animal and cellular levels, respectively....
Paper Details
Title
Silencing of miR-138-5p sensitizes bone anabolic action to mechanical stimuli
Published Date
Jan 1, 2020
Volume
10
Issue
26
Pages
12263 - 12278
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