Complement Expression and Activation in Osteoarthritis Joint Compartments

Objective. To investigate complement(C) factors(F) and their activation fragments expression in OA joint tissues. Design. Immunohistochemistry and quantitative Imaging were performed to analyze C3, C4 and CF (factor) B expression on osteochondral biopsies (43 patients) collected during arthroplasty. Isolated chondrocytes and synoviocytes, cartilage and synovial tissues obtained from surgical specimens of OA patients (15 patients) were cultured...