Transforming approaches to treating TRK fusion cancer: historical comparison of larotrectinib and histology-specific therapies

Objective The results from basket trials utilized to gain regulatory approval of tumor-agnostic therapies can be difficult to interpret without the context of a comparator arm. We describe the role and efficacy of histology-based treatments to provide a historical comparison with larotrectinib.Methods A systematic literature review (SLR) was conducted on the clinical outcomes of current histology-based standard of care treatments used in...