MyD88/CD40 signaling retains CAR T cells in a less differentiated state
Abstract
Chimeric antigen receptor (CAR) T cell therapy for solid tumors has shown limited efficacy in early-phase clinical studies. The majority of CARs encode CD28 and/or 41BB costimulatory endodomains, and we explored whether MyD88 and CD40 (MC) costimulatory endodomains in CARs could improve their antitumor activity. We generated CD28-, 41BB-, and MC-CAR T cells and demonstrated that MC-CAR T cells have greater proliferative capacity and antitumor...
Paper Details
Title
MyD88/CD40 signaling retains CAR T cells in a less differentiated state
Published Date
Nov 5, 2020
Journal
Volume
5
Issue
21
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