Preparation and characterization of a three dimensional porous poly(lactic-co-glycolic acid)/mesoporous silica nanoparticles scaffold by low-temperature deposition manufacturing

In this study, we introduced mesoporous silica nanoparticles (MSNs) into poly(lactic-co-glycolic acid) (PLGA) to prepare a novel three dimensional (3D) porous scaffold by low-temperature deposition manufacturing (LDM). During the scaffolds preparing process, LDM managed to fabricate scaffolds with 3D geometry and desirable big pore structures but not damage the bioactivity of biomaterials. In the subsequent freeze-drying process, the...