Synthesis, urease inhibition screening and molecular docking studies of piperonal based imine derivatives

Volume: 30, Issue: 1, Pages: 226 - 235
Published: Oct 31, 2020
Abstract
A series of piperonal-based imines (3a–c) and bis-imines (5a-o) have been synthesized in search of new urease inhibitors. Synthesized compounds were characterized by 1H NMR, 13C NMR and EI-MS. These derivatives were subjected to evaluation of urease inhibitory potential, which exhibited a varied degree of potential, ranging from 41.7 ± 5.8 to 353.6 ± 5.8 µM, when compared with the standard inhibitor (i.e., thiourea having IC50 value...
Paper Details
Title
Synthesis, urease inhibition screening and molecular docking studies of piperonal based imine derivatives
Published Date
Oct 31, 2020
Volume
30
Issue
1
Pages
226 - 235
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