siRNA Nanoparticle Suppresses Drug‐Resistant Gene and Prolongs Survival in an Orthotopic Glioblastoma Xenograft Mouse Model
Abstract
Temozolomide (TMZ) is the standard of care chemotherapy drug for treating glioblastomas (GBMs), the most aggressive cancer that affects people of all ages. However, its therapeutic efficacy is limited by the drug resistance mediated by a DNA repair protein, O6-methylguanine-DNA methyltransferase (MGMT), which eliminates the TMZ-induced DNA lesions. Here we report the development of an iron oxide nanoparticle (NP) system for targeted delivery of...
Paper Details
Title
siRNA Nanoparticle Suppresses Drug‐Resistant Gene and Prolongs Survival in an Orthotopic Glioblastoma Xenograft Mouse Model
Published Date
Nov 6, 2020
Volume
31
Issue
6
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