Drug‐specific T‐cell responses in patients with liver injury following treatment with the BACE inhibitor atabecestat

Background Atabecestat is an orally administered BACE inhibitor developed to treat Alzheimer's disease. Elevations in hepatic enzymes were detected in a number of in trial patients, which resulted in termination of the drug development programme. Immunohistochemical characterization of liver tissue from an index case of atabecestat‐mediated liver injury revealed an infiltration of T‐lymphocytes in areas of hepatocellular damage. This coupled...