Viperin binds STING and enhances the type‐I interferon response following dsDNA detection
Abstract
Viperin is an interferon‐inducible protein that is pivotal for eliciting an effective immune response against an array of diverse viral pathogens. Here we describe a mechanism of viperin’s broad antiviral activity by demonstrating the protein’s ability to synergistically enhance the innate immune dsDNA signaling pathway to limit viral infection. Viperin co‐localized with the key signaling molecules of the innate immune dsDNA sensing pathway,...
Paper Details
Title
Viperin binds STING and enhances the type‐I interferon response following dsDNA detection
Published Date
Nov 22, 2020
Journal
Volume
99
Issue
4
Pages
373 - 391
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