Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression
Abstract
Tumor necrosis commonly exists and predicts poor prognoses in many cancers. Although it is thought to result from chronic ischemia, the underlying nature and mechanisms driving the involved cell death remain obscure. Here, we show that necrosis in glioblastoma (GBM) involves neutrophil-triggered ferroptosis. In a hyperactivated transcriptional coactivator with PDZ-binding motif-driven GBM mouse model, neutrophils coincide with necrosis...
Paper Details
Title
Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression
Published Date
Oct 27, 2020
Journal
Volume
11
Issue
1
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