Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
Abstract
Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline....
Paper Details
Title
Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
Published Date
Apr 1, 2021
Journal
Volume
99
Issue
4
Pages
926 - 939
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