Association of Uncommon, Noncoding Variants in the APOE Region With Risk of Alzheimer Disease in Adults of European Ancestry
Abstract
Importance
The ε2 and ε4 alleles of the apolipoprotein E (APOE) gene are associated with Alzheimer disease (AD) risk. Although nearby genetic variants have also been shown to be associated with AD, including rs2075650 in theTOMM40gene and rs4420638 near theAPOC1gene, it is unknown whether these associations are independent of the ε2 and ε4 alleles.Objective
To assess whether variants nearAPOEare...Paper Details
Title
Association of Uncommon, Noncoding Variants in the APOE Region With Risk of Alzheimer Disease in Adults of European Ancestry
Published Date
Oct 22, 2020
Journal
Volume
3
Issue
10
Pages
e2017666 - e2017666
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Notes
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