Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress
Abstract
T-LAK-originated protein kinase (TOPK) overexpression is a feature of multiple cancers, yet is absent from most phenotypically normal tissues. As such, TOPK expression profiling and the development of TOPK-targeting pharmaceutical agents have raised hopes for its future potential in the development of targeted therapeutics. Results presented in this paper confirm the value of TOPK as a potential target for the treatment of solid tumours, and...
Paper Details
Title
Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress
Published Date
Nov 9, 2020
Journal
Volume
28
Issue
4
Pages
1333 - 1346
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