Do Polygenic Risk Scores For Cancer Susceptibility Associate With Risk Of Radiotherapy Toxicity?

Single nucleotide polymorphisms (SNPs) associated with increased susceptibility to cancer frequently lie in genes that might also modulate response to radiation. The purpose of this study is to evaluate whether individuals at increased genetic risk of developing cancer are also more likely to develop late radiotherapy-induced toxicities. We test the hypothesis that polygenic risk scores (PRS) for cancer susceptibility alter toxicity risk among...