Trigonelline inhibits Nrf2 via EGFR signalling pathway and augments efficacy of Cisplatin and Etoposide in NSCLC cells
Abstract
Constitutive high expression of Nrf2 (Nuclear factor erythroid 2-related factor 2) is an important contributor of proliferation and chemoresistance in Non-small cell lung cancer (NSCLC). The aim of this present study was to investigate the Nrf2 inhibitory effect of Trigonelline, its mechanism of action and its possible use in combinatorial treatment with anti- lung cancer drugs, Cisplatin and Etoposide. Our immunofluorescence, western blot and...
Paper Details
Title
Trigonelline inhibits Nrf2 via EGFR signalling pathway and augments efficacy of Cisplatin and Etoposide in NSCLC cells
Published Date
Feb 1, 2021
Journal
Volume
70
Pages
105038 - 105038
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