E-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow

Volume: 11, Issue: 1, Pages: 5397 - 5397
Published: Oct 26, 2020
Abstract
The migration of many cell types relies on the formation of actomyosin-dependent protrusions called blebs, but the mechanisms responsible for focusing this kind of protrusive activity to the cell front are largely unknown. Here, we employ zebrafish primordial germ cells (PGCs) as a model to study the role of cell-cell adhesion in bleb-driven single-cell migration in vivo. Utilizing a range of genetic, reverse genetic and mathematical tools, we...
Paper Details
Title
E-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow
Published Date
Oct 26, 2020
Volume
11
Issue
1
Pages
5397 - 5397
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