Relevance of B and NK Cells in the Correlation between Radiation-induced Lymphocyte Apoptosis (RILA) and Normal-tissue Late Toxicity after Radiotherapy

Radiation-induced lymphocyte apoptosis (RILA) after in vitro irradiation of T cells is a promising predictive assay for the late effects of radiotherapy (RT). Previously, we showed a significant association between the apoptosis rates in several T cell populations and the late effects 10 years after RT for the treatment of breast cancer (Veldwijk et al. Clin. Cancer Res. 2019). NK cells were also tested, which however proved to be extremely...