Analysis of tricyclic antidepressants in pharmaceuticals by microemulsion liquid chromatography

Volume: 160, Pages: 105659 - 105659
Published: Jan 1, 2021
Abstract
Basic compounds yield long retention times and broad and asymmetric peaks in reversed-phase liquid chromatography, due to interaction with residual silanols in the columns. The addition of the surfactant sodium dodecyl sulphate in the so called micellar liquid chromatography enhances the efficiency, but long retention is achieved, due to electrostatic interaction between the cationic species of basic compounds and the anionic sulphate group of...
Paper Details
Title
Analysis of tricyclic antidepressants in pharmaceuticals by microemulsion liquid chromatography
Published Date
Jan 1, 2021
Volume
160
Pages
105659 - 105659
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