Solubility measurement, thermodynamic correlation and molecular dynamic simulation of naphazoline hydrochloride in four binary solvents

Laser monitoring technique was used for the determination of solid-liquid equilibrium solubility of naphazoline hydrochloride (NPZ) in four binary solvents (methanol + ethanol, methanol + isopropanol, 2-methoxyethanol + isopropanol and methanol + ethyl acetate) at T = (278.15–323.15) K and pressure p = 0.1 MPa. In all cases, solubility of NPZ raised with the increment of temperature. The results also indicated that the addition of positive...