Regulation of hepatic stellate cell contraction and cirrhotic portal hypertension by Wnt/β‐catenin signalling via interaction with Gli1

Volume: 178, Issue: 11, Pages: 2246 - 2265
Published: Apr 14, 2021
Abstract
Background and Purpose Portal hypertension is a lethal complication of cirrhosis. Its mechanism and therapeutic targets remain largely unknown. Hepatic stellate cell (HSC) contraction increases intrahepatic vascular resistance contributing to portal hypertension. We investigated how HSC contraction was regulated by Wnt signalling and the therapeutic implications. Experimental Approach Liver tissues from cirrhotic patients were examined....
Paper Details
Title
Regulation of hepatic stellate cell contraction and cirrhotic portal hypertension by Wnt/β‐catenin signalling via interaction with Gli1
Published Date
Apr 14, 2021
Volume
178
Issue
11
Pages
2246 - 2265
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