Knowledge-Based VMAT Planning of Total Marrow Irradiation as a Part of Conditioning Regimen Before Allo-SCT in a Prospective Phase I/II Study

Total marrow irradiation (TMI) involves optimization of extremely large target volumes and requires extended time for treatment planning and delivery. Although volumetric modulated arc therapy (VMAT) achieves substantial reduction in the delivery time, the planning process still presents a challenge with multiple isocenters and multiple overlapping arcs to adequately cover sub-target volumes of head and neck, chest, and pelvis. We developed and...