The aortic root in repaired tetralogy of Fallot: Serial measurements and impact of losartan treatment

Aortic root dilatation is common in adults with repaired tetralogy of Fallot (rTOF) and might lead to aortic dissection. However, little is known on progression of aortic dilatation and the effect of pharmaceutical treatment. This study aims to determine factors associated with aortic growth and investigate effects of losartan.We performed a prespecified analysis from the 1:1 randomized, double-blind REDEFINE trial. Aortic root diameters were...