ABRO1 stabilizes the deubiquitinase BRCC3 through inhibiting its degradation mediated by the E3 ubiquitin ligase WWP2
Abstract
BRCA1/BRCA2‐containing complex subunit 3 (BRCC3) is a lysine 63‐specific deubiquitinase involved in multiple biological processes, such as DNA repair and immune responses. However, the regulation mechanism for BRCC3 protein stability is still unknown. Here, we demonstrate that BRCC3 is mainly degraded through the ubiquitin‐proteasome pathway. The HECT‐type E3 ubiquitin ligase WWP2 modulates BRCC3 ubiquitination and degradation. ABRO1, a subunit...
Paper Details
Title
ABRO1 stabilizes the deubiquitinase BRCC3 through inhibiting its degradation mediated by the E3 ubiquitin ligase WWP2
Published Date
Nov 8, 2020
Journal
Volume
595
Issue
2
Pages
169 - 182
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