Toward a Consensus View of Mammalian Adipocyte Stem and Progenitor Cell Heterogeneity

The adipose stem and progenitor cell (ASPC) fraction is heterogeneous and comprises at least three subpopulations: adipose stem cells (ASCs), preadipocytes (PreAs), and adipogenesis regulators (Aregs).ASCs (DPP4+, CD55+) give rise to both PreAs (ICAM1+, VAP-1+) and Aregs (CD142+).In adult mice, Aregs (CD142+) inhibit adipogenesis through paracrine mechanisms, which are not yet fully understood.In visceral fat, a subpopulation of ASCs, known as...