Increased S1P expression in osteoclasts enhances bone formation in an animal model of Paget's disease

Paget's disease (PD) is characterized by increased numbers of abnormal osteoclasts (OCLs) that drive exuberant bone formation, but the mechanisms responsible for the increased bone formation remain unclear. We previously reported that OCLs from 70% of PD patients express measles virus nucleocapsid protein ( MVNP ), and that transgenic mice with targeted expression of MVNP in OCLs ( MVNP mice) develop bone lesions and abnormal OCLs characteristic...