S0384 Towards a Better Understanding of Pathophysiology in Patients With PPI-Refractory GERD: Study of Demographics, Symptoms, and Esophageal Manometry

INTRODUCTION: Introduction: Gastroesophageal reflux disease (GERD) is common and up to 1/3 of patients may have symptoms that are refractory to PPI therapy. High-resolution esophageal manometry has been used to identify abnormal peristalsis and major motor disorders in this population together with ambulatory pH monitoring. Our aim was to evaluate the demographic features and pathophysiological mechanisms in patients with PPI-refractory GERD....