Quantification of Myelinated Nerve Fraction and Degeneration in Spinal Cord Neuropil by SHIFT MRI

Background Neurodegeneration is a complex cellular process linked to prompt changes in myelin integrity and gradual neuron loss. Current imaging techniques offer estimations of myelin volumes in lesions/remyelinated areas but are limited to detect subtle injury. Purpose To investigate whether measurements detected by a signal hierarchically isolated as a function of time‐to‐echo (SHIFT) MRI technique can determine changes in myelin integrity and...