Network pharmacology-based investigation on the mechanisms of action of Morinda officinalis How. in the treatment of osteoporosis.

Published on Dec 1, 2020in Computers in Biology and Medicine3.434
· DOI :10.1016/J.COMPBIOMED.2020.104074
Zhi-Wen Liu1
Estimated H-index: 1
(Guangzhou University of Chinese Medicine),
Zhuo-Hui Luo2
Estimated H-index: 2
(Guangzhou University of Chinese Medicine)
+ 3 AuthorsXiao-Ling Shen7
Estimated H-index: 7
(Guangzhou University of Chinese Medicine)
Abstract Background Osteoporosis is a systemic skeletal disease that leads to a high risk for bone fractures. Morinda officinalis How. has been used as osteoporosis treatment in China. However, its mechanism of action as an anti-osteoporotic herb remains unknown. Methods A network pharmacology approach was applied to explore the potential mechanisms of action of M. officinalis in osteoporosis treatment. The active compounds of M. officinalis and their potential osteoporosis-related targets were retrieved from TCMSP, TCMID, SwissTargetPrediction, DrugBank, DisGeNET, GeneCards, OMIM, and TTD databases. A protein–protein interaction network was built to analyze the target interactions. The Metascape database was used to carry out GO enrichment analysis and KEGG pathway analysis. Moreover, interactions between active compounds and potential targets were investigated through molecular docking. Results A total of 17 active compounds and 93 anti-osteoporosis targets of M. officinalis were selected for analysis. The GO enrichment analysis results indicated that the anti-osteoporosis targets of M. officinalis mainly play a role in the response to steroid hormone. The KEGG pathway enrichment analysis showed that M. officinalis prevents osteoporosis through the ovarian steroidogenesis signaling pathway. Moreover, the molecular docking results indicated that bioactive compounds (morindon, ohioensin A, and physcion) demonstrated a good binding ability with IGF1R, INSR, ESR1, and MMP9. Conclusion M. officinalis contains potential anti-osteoporotic active compounds. These compounds function by regulating the proteins implicated in ovarian steroidogenesis-related pathways that are crucial in estrogen biosynthesis. Our study provides new insights into the development of a natural therapy for the prevention and treatment of osteoporosis.
📖 Papers frequently viewed together
13 Authors (Tao Yu, ..., Kai Chen)
2 Citations
12 Authors (Tao Yu, ..., Yunfeng Yang)
8 Authors (Jing Lin, ..., Ling Wang)
19 Citations
#1Yueping Li (Shihezi University)H-Index: 1
#2Chi Xu (Fujian Medical University)H-Index: 1
Last. Yonghua Wang (Northwest University (United States))H-Index: 34
view all 12 authors...
Abstract Ethnopharmacological relevance Cardiomyopathy is a common cause of heart failure and may lead to increased risk of sudden cardiac death, lacking simple, safe and effective treatment strategies due to unclear pathogenesis. Ginkgo biloba L. leaves (GBLs), a traditional Chinese medicine (TCM), has been widely used in clinical medicine for improving blood circulation, and was demonstrated to be effective on cardiomyopathy in preclinical studies. However, because of the widely known holistic...
1 CitationsSource
#1Huiqi Li (University of Gothenburg)H-Index: 10
#2Maria Wallin (University of Gothenburg)H-Index: 1
Last. Eva Andersson (University of Gothenburg)H-Index: 10
view all 8 authors...
Cigarette smoking is a risk factor for osteoporosis and bone fracture. Moreover, smoking causes exposure to cadmium, which is a known risk factor for osteoporosis. It is hypothesized that part of smoking-induced osteoporosis may be mediated via cadmium from tobacco smoke. We investigated this hypothesis using mediation analysis in a Swedish cohort of elderly men. This study was performed in 886 elderly men from the Swedish cohort of the Osteoporotic Fractures in Men (MrOS) study. Urinary samples...
9 CitationsSource
#1Zhixia Qiu (CPU: China Pharmaceutical University)H-Index: 10
#2Jingjing Dong (CPU: China Pharmaceutical University)H-Index: 1
Last. Fang Huang (CPU: China Pharmaceutical University)H-Index: 16
view all 8 authors...
Abstract Ethnopharmacological relevance Polycystic ovary syndrome (PCOS) is a complex gynecological endocrine disease commonly occurred in women of childbearing age. The main hallmark of PCOS includes elevated androgen production and insulin resistance (IR). Liuwei Dihuang Pills (LWDH Pills), a commonly prescribed traditional Chinese medicine (TCM) is widely used as a tonic prescription to treat diabetes, female menopause syndrome and other symptoms with‘Kidney-Yin’ deficiency. It has been repor...
9 CitationsSource
#1Yunxia Wang (ZJU: Zhejiang University)H-Index: 9
#2Song Zhang (ZJU: Zhejiang University)H-Index: 3
Last. Feng Zhu (ZJU: Zhejiang University)H-Index: 41
view all 15 authors...
Knowledge of therapeutic targets and early drug candidates is useful for improved drug discovery. In particular, information about target regulators and the patented therapeutic agents facilitates research regarding druggability, systems pharmacology, new trends, molecular landscapes, and the development of drug discovery tools. To complement other databases, we constructed the Therapeutic Target Database (TTD) with expanded information about (i) target-regulating microRNAs and transcription fac...
110 CitationsSource
#1Wenjuan Zhang (NPU: Northwestern Polytechnical University)H-Index: 4
#2Kaiyue Xue (NPU: Northwestern Polytechnical University)H-Index: 2
Last. Airong Qian (NPU: Northwestern Polytechnical University)H-Index: 26
view all 9 authors...
Abstract Aims Osteoporosis (OP) is a systemic metabolic bone disease characterized by bone mass decrease and microstructural degradation, which may increase the risk of bone fracture and leading to high morbidity. Dipsaci Radix (DR), one typical traditional Chinese medicine (TCM), which has been applied in the treatment of OP with good therapeutic effects and few side effects. However, the underlying molecular mechanisms of DR to treat OP have not been fully elucidated. In this study, we aim to ...
8 CitationsSource
#1Yu-Ru V. Shih (Duke University)H-Index: 19
#2Mengqian Liu (Duke University)H-Index: 3
Last. Shyni Varghese (Duke University)H-Index: 41
view all 7 authors...
Adenosine and its receptors play a key role in bone homeostasis and regeneration. Extracellular adenosine is generated from CD39 and CD73 activity in the cell membrane, through conversion of adenosine triphosphate to adenosine monophosphate (AMP) and AMP to adenosine, respectively. Despite the relevance of CD39/CD73 to bone health, the roles of these enzymes in bona fide skeletal disorders remain unknown. We demonstrate that CD39/CD73 expression and extracellular adenosine levels in the bone mar...
17 CitationsSource
#1Chunyan Yan (Guangdong Pharmaceutical University)H-Index: 16
#1Chunyan Yan (Guangdong Pharmaceutical University)H-Index: 6
Last. Qian Zhang (Guangdong Pharmaceutical University)H-Index: 9
view all 7 authors...
Abstract Morinda officinalis is an important traditional tonic herbal medicine. In the present study, we found that crude polysaccharides extracted from M. officinalis, named MO90, could significantly increase the bone mineral density (BMD) of the whole femur, distal femur, and proximal femur in ovariectomized (OVX) rats. In addition, MO90 decreased the level of bone turnover markers and prevented the deterioration of trabecular microarchitecture. To investigate the fractions responsible for ant...
8 CitationsSource
#1Yuxiang Wan (Beijing University of Chinese Medicine)H-Index: 3
#2Lin Xu (Beijing University of Chinese Medicine)H-Index: 2
Last. Jinchang Huang (Beijing University of Chinese Medicine)H-Index: 1
view all 7 authors...
Background Wumei Pill (WMP), a famous herbal formula, has been widely used to treat digestive system diseases in clinical practice in China for centuries. We have found a correlation between the indications of WMP and the typical symptoms of pancreatic neoplasms. However, the pharmacological mechanisms of WMP still remain unknown.
27 CitationsSource
#1Antoine Daina (Swiss Institute of Bioinformatics)H-Index: 9
#2Olivier Michielin (Swiss Institute of Bioinformatics)H-Index: 4
Last. Vincent Zoete (Swiss Institute of Bioinformatics)H-Index: 41
view all 3 authors...
: SwissTargetPrediction is a web tool, on-line since 2014, that aims to predict the most probable protein targets of small molecules. Predictions are based on the similarity principle, through reverse screening. Here, we describe the 2019 version, which represents a major update in terms of underlying data, backend and web interface. The bioactivity data were updated, the model retrained and similarity thresholds redefined. In the new version, the predictions are performed by searching for simil...
199 CitationsSource
#1Yingyao Zhou (Genomics Institute of the Novartis Research Foundation)H-Index: 40
#2Bin Zhou (Genomics Institute of the Novartis Research Foundation)H-Index: 65
Last. Sumit K. Chanda (DI: Discovery Institute)H-Index: 37
view all 8 authors...
A critical component in the interpretation of systems-level studies is the inference of enriched biological pathways and protein complexes contained within OMICs datasets. Successful analysis requires the integration of a broad set of current biological databases and the application of a robust analytical pipeline to produce readily interpretable results. Metascape is a web-based portal designed to provide a comprehensive gene list annotation and analysis resource for experimental biologists. In...
1,341 CitationsSource
Cited By0