Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease
Abstract
The etiology of the common, sporadic form of Alzheimer's disease (sAD) is unknown. We hypothesize that tau pathology within select projection neurons with susceptible microenvironments can initiate sAD. This postulate rests on extensive data demonstrating that in human brains tau pathology appears about a decade before the formation of Aβ plaques (Aβps), especially targeting glutamate projection neurons in the association cortex. Data from aging...
Paper Details
Title
Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease
Published Date
Oct 19, 2020
Journal
Volume
17
Issue
1
Pages
115 - 124
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