57P Functional inactivation of E-cadherin by Trop-2 drives cancer metastasis

Metastatic disease is the dominant cause of death in cancer patients. Hundreds of proteins/genes have been linked to the metastatic phenotype. However, neither proteomic analysis nor large-scale genome sequencing succeeded in identifying consistent markers of tumour aggressiveness and metastatic potential in cancer patients. In vitro cellular assays were utilized to identify signal transduction networks and for dynamic imaging of fluorescent...