The glutathione system in Parkinson’s disease and its progression

Redox dysfunctions and neuro-oxidative stress play a major role in the pathophysiology and progression of Parkinson’s disease (PD). Glutathione (GSH) and the reduced/oxidized glutathione (GSH/GSSG) ratio are lowered in oxidative stress conditions and may lead to increased oxidative toxicity. GSH is involved not only in neuro-immune and neuro-oxidative processes, including thiol redox signaling, but also in cell proliferation and differentiation...