Dual Targeting of Cancer Cells with DARPin-Based Toxins for Overcoming Tumor Escape.

Volume: 12, Issue: 10, Pages: 3014
Published: Oct 16, 2020
Abstract
We report here a combined anti-cancer therapy directed toward HER2 and EpCAM, common tumor-associated antigens of breast cancer cells. The combined therapeutic effect is achieved owing to two highly toxic proteins-a low immunogenic variant of Pseudomonas aeruginosa exotoxin A and ribonuclease Barnase from Bacillus amyloliquefaciens. The delivery of toxins to cancer cells was carried out by targeting designed ankyrin repeat proteins (DARPins). We...
Paper Details
Title
Dual Targeting of Cancer Cells with DARPin-Based Toxins for Overcoming Tumor Escape.
Published Date
Oct 16, 2020
Journal
Volume
12
Issue
10
Pages
3014
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