The antidiabetic drug glibenclamide exerts direct retinal neuroprotection
Abstract
Sulfonylureas, widely used as hypoglycemic agents in adults with type 2 diabetes, have neuroprotective effects in preclinical models of central nervous system injury, and in children with neuropsychomotor impairments linked to neonatal diabetes secondary to ATP-sensitive potassium channel mutations. In the human and rodent retina, we show that the glibenclamide-activated channel sulfonylurea receptor 1 (SUR1) is expressed in the retina and...
Paper Details
Title
The antidiabetic drug glibenclamide exerts direct retinal neuroprotection
Published Date
Mar 1, 2021
Journal
Volume
229
Pages
83 - 99
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