Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment.
Abstract
The tumor microenvironment is crucial for the growth of cancer cells, triggering particular biochemical and physiological changes, which frequently influence the outcome of anticancer therapies. The biochemical rationale behind many of these phenomena resides in the activation of transcription factors such as hypoxia-inducible factor 1 and 2 (HIF-1/2). In turn, the HIF pathway activates a number of genes including those involved in glucose...
Paper Details
Title
Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment.
Published Date
Oct 14, 2020
Journal
Volume
10
Issue
10
Pages
412
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Notes
History