APOE2 is associated with longevity independent of Alzheimer’s disease
Abstract
Although the ε2 allele of apolipoprotein E (APOE2) benefits longevity, its mechanism is not understood. The protective effects of the APOE2 on Alzheimer's disease (AD) risk, particularly through their effects on amyloid or tau accumulation, may confound APOE2 effects on longevity. Herein, we showed that the association between APOE2 and longer lifespan persisted irrespective of AD status, including its neuropathology, by analyzing clinical...
Paper Details
Title
APOE2 is associated with longevity independent of Alzheimer’s disease
Published Date
Oct 19, 2020
Journal
Volume
9
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