Bleomycin: A novel osteogenesis inhibitor of dental follicle cells via a TGF‐β1/SMAD7/RUNX2 pathway

Volume: 178, Issue: 2, Pages: 312 - 327
Published: Dec 13, 2020
Abstract
Background and purpose null Tooth eruption is a complicated process regulated by the dental follicles (DF). Our recent study discovered that tooth eruption was inhibited upon injection of bleomycin into DF. However, the mechanisms were unknown. null Experimental approach null Human dental follicle cells (hDFCs) were treated by bleomycin or exogenous TGF-β1 or transfected by plasmids loading SMAD7 or shRNA targeting SMAD7, followed by...
Paper Details
Title
Bleomycin: A novel osteogenesis inhibitor of dental follicle cells via a TGF‐β1/SMAD7/RUNX2 pathway
Published Date
Dec 13, 2020
Volume
178
Issue
2
Pages
312 - 327
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