Anti-adipogenicadamantane type polycyclic polyprenylated acylphloroglucinols from Hypericum subsessile

Hypersubones D–H (1–5), five new polycyclic polyprenylated acylphloroglucinols (PPAPs) type metabolites with intriguing adamantane and homo-adamantane skeletons, were characterized from aerial parts of Hypericum subsessile. Compounds 1–2 were elucidated to share an adamantane core with 28,29-expoxide moiety, while 3–5 were homo-adamantane type PPAPs sharing a1,2-dioxepane ring system. Their structures were determined on the basis of...