Electrospray ionization and heterogeneous matrix effects in liquid chromatography/mass spectrometry based meta‐metabolomics: A biomarker or a suppressed ion?

Rationale Correct biomarker determination in metabolomics is crucial for unbiased conclusions and reliable applications. However, this determination is subject to several drifts, e.g. matrix effects and ion suppression in Liquid Chromatography/Mass Spectrometry (LC/MS)‐based approaches. This phenomenon provokes critical issues for biomarker determination, particularly during comparative studies dealing with samples exhibiting heterogeneous...