An optimal “Click” formulation strategy for antibody-drug conjugate synthesis

Volume: 28, Issue: 24, Pages: 115808 - 115808
Published: Dec 1, 2020
Abstract
As a versatile reaction for bioconjugation, Cu(I)-catalyzed alkyne-azide cycloaddition (CuAAC) has enormous potential in the synthesis of antibody-drug conjugates (ADCs). In order to optimize CuAAC-based ADC synthesis, we characterized kinetically different formulation processes by mimicking ADC synthesis using small molecules and subsequently revealed unique kinetic behaviors of different combinations of alkyne and azide conditions. Our results...
Paper Details
Title
An optimal “Click” formulation strategy for antibody-drug conjugate synthesis
Published Date
Dec 1, 2020
Volume
28
Issue
24
Pages
115808 - 115808
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