Dynamics of genomic and immune responses during primary immunotherapy resistance in mismatch repair–deficient tumors
Volume: 6, Issue: 5, Pages: a005678 - a005678
Published: Oct 1, 2020
Abstract
Mismatch repair–deficient (dMMR) cancers generate a substantial number of immunogenic neoantigens, rendering them sensitive to immunotherapy. Yet, there is considerable variability in responses, and roughly one-half of dMMR cancers are refractory to immunotherapy. Here we study a patient with dMMR lung cancer refractory to immunotherapy. The tumor exhibited typical dMMR molecular features, including exceptionally high frameshift insertions and...
Paper Details
Title
Dynamics of genomic and immune responses during primary immunotherapy resistance in mismatch repair–deficient tumors
Published Date
Oct 1, 2020
Volume
6
Issue
5
Pages
a005678 - a005678
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