Transbuccal delivery of metal complexes of isoniazid as an alternative to overcome antimicrobial resistance problems

In isolated isoniazid (INH)-resistant strains, deletion or mutations in the katG gene have been identified, which result in loss of catalase-peroxidase activity. This enzyme plays a key role in the activation of this prodrug. As an alternative, the coordination of the INH to metal complexes has been purposed to activate it regardless of enzyme functionality. Although pentacyanido(isoniazid)ferrate(II) complexes have shown to be effective against...