An aberrant STAT pathway is central to COVID-19

Volume: 27, Issue: 12, Pages: 3209 - 3225
Published: Oct 9, 2020
Abstract
COVID-19 is caused by SARS-CoV-2 infection and characterized by diverse clinical symptoms. Type I interferon (IFN-I) production is impaired and severe cases lead to ARDS and widespread coagulopathy. We propose that COVID-19 pathophysiology is initiated by SARS-CoV-2 gene products, the NSP1 and ORF6 proteins, leading to a catastrophic cascade of failures. These viral components induce signal transducer and activator of transcription 1 (STAT1)...
Paper Details
Title
An aberrant STAT pathway is central to COVID-19
Published Date
Oct 9, 2020
Volume
27
Issue
12
Pages
3209 - 3225
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