Biphasic effect of metformin on human cardiac energetics
Abstract
Metformin is the first-line medication for treatment of type 2 diabetes and has been shown to reduce heart damage and death. However, mechanisms by which metformin protects human heart remain debated. The aim of the study was to evaluate the cardioprotective effect of metformin on cardiomyocytes derived from human-induced pluripotent stem cells (hiPSC-CMs) and mitochondria isolated from human cardiac tissue. At concentrations ≤2.5 mM, metformin...
Paper Details
Title
Biphasic effect of metformin on human cardiac energetics
Published Date
Mar 1, 2021
Journal
Volume
229
Pages
5 - 23
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